Effect of amiodarone on the phospholipid and lamellar body content of lymphoblasts in vitro and peripheral blood lymphocytes in vivo
Identifieur interne : 002F79 ( Main/Exploration ); précédent : 002F78; suivant : 002F80Effect of amiodarone on the phospholipid and lamellar body content of lymphoblasts in vitro and peripheral blood lymphocytes in vivo
Auteurs : Karl Y. Hostetler [États-Unis] ; Jerry Vande Berg [États-Unis] ; Kathy A. Aldern [États-Unis] ; Gregory T. Brophy [États-Unis]Source :
- Biochemical Pharmacology [ 0006-2952 ] ; 1991.
English descriptors
- Teeft :
- Adverse effects, Amiodarone, Amiodarone concentration, Amiodarone effect, Amiodarone toxicity, Amiodarone treatment, Biochim biophys acta, Biol chem, Cationic amphiphilic drugs, Cell pellets, Cell suspensions, Consecutive cells, Control lymphoblasts, Control subjects, Cultured lymphoblasts, Cumulative dose, Drug concentration, Electron microscopy, Inclusion, Lamellar, Lamellar bodies, Lamellar body content, Lamellar inclusions, Lilly research laboratories, Liver toxicity, Lymphoblast, Lymphocyte, Lymphocyte phospholipid levels, Lysosomal, Lysosomal phospholipase, Many tissues, Multilamellar, Multilamellar inclusion, Multilamellar inclusions, Normal lymphoblasts, Peripheral blood lymphocytes, Phospholipase, Phospholipid, Phospholipid accumulation, Phospholipid content, Plasma levels, Pulmonary toxicity, Rpm1 medium, Serum level, Toxic effects, Toxicity, Ventricular arrhythmias, Veterans administration.
Abstract
Abstract: Amiodarone is useful for the treatment of ventricular arrhythmias but has been associated with a significant degree of toxicity especially to lung and liver. The drug produces phospholipid accumulation in multilamella lysosomal inclusions in many tissues due to the ability of amiodarone and desethylamiodarone to inhibit phospholipase A. The adverse effects do not correlate with the plasma levels of amiodarone but relate more closely to the cumulative dose. No clear way of predicting amiodarone toxicity has yet emerged. In this report, normal human lymphoblasts in tissue culture were shown by electron microscopy to have dose-dependent increases in multilamellar inclusions when grown with amiodarone at concentrations which are routinely observed in patients receiving the drug. The content of phospholipid also increased but this parameter was not as sensitive as the number of multilamellar inclusions. Finally, lymphocytes from patients treated with amiodarone were examined by electron microscopy and shown to have increased numbers of multilamellar bodies.
Url:
DOI: 10.1016/0006-2952(91)90208-M
Affiliations:
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Brophy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Lilly Research Laboratories, Greenfield, IN 46140</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Biochemical Pharmacology</title><title level="j" type="abbrev">BCP</title><idno type="ISSN">0006-2952</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1991">1991</date><biblScope unit="volume">41</biblScope><biblScope unit="issue">6–7</biblScope><biblScope unit="page" from="1007">1007</biblScope><biblScope unit="page" to="1013">1013</biblScope></imprint><idno type="ISSN">0006-2952</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-2952</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adverse effects</term><term>Amiodarone</term><term>Amiodarone concentration</term><term>Amiodarone effect</term><term>Amiodarone toxicity</term><term>Amiodarone treatment</term><term>Biochim biophys acta</term><term>Biol chem</term><term>Cationic amphiphilic drugs</term><term>Cell pellets</term><term>Cell suspensions</term><term>Consecutive cells</term><term>Control lymphoblasts</term><term>Control subjects</term><term>Cultured lymphoblasts</term><term>Cumulative dose</term><term>Drug concentration</term><term>Electron microscopy</term><term>Inclusion</term><term>Lamellar</term><term>Lamellar bodies</term><term>Lamellar body content</term><term>Lamellar inclusions</term><term>Lilly research laboratories</term><term>Liver toxicity</term><term>Lymphoblast</term><term>Lymphocyte</term><term>Lymphocyte phospholipid levels</term><term>Lysosomal</term><term>Lysosomal phospholipase</term><term>Many tissues</term><term>Multilamellar</term><term>Multilamellar inclusion</term><term>Multilamellar inclusions</term><term>Normal lymphoblasts</term><term>Peripheral blood lymphocytes</term><term>Phospholipase</term><term>Phospholipid</term><term>Phospholipid accumulation</term><term>Phospholipid content</term><term>Plasma levels</term><term>Pulmonary toxicity</term><term>Rpm1 medium</term><term>Serum level</term><term>Toxic effects</term><term>Toxicity</term><term>Ventricular arrhythmias</term><term>Veterans administration</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Amiodarone is useful for the treatment of ventricular arrhythmias but has been associated with a significant degree of toxicity especially to lung and liver. The drug produces phospholipid accumulation in multilamella lysosomal inclusions in many tissues due to the ability of amiodarone and desethylamiodarone to inhibit phospholipase A. The adverse effects do not correlate with the plasma levels of amiodarone but relate more closely to the cumulative dose. No clear way of predicting amiodarone toxicity has yet emerged. In this report, normal human lymphoblasts in tissue culture were shown by electron microscopy to have dose-dependent increases in multilamellar inclusions when grown with amiodarone at concentrations which are routinely observed in patients receiving the drug. The content of phospholipid also increased but this parameter was not as sensitive as the number of multilamellar inclusions. Finally, lymphocytes from patients treated with amiodarone were examined by electron microscopy and shown to have increased numbers of multilamellar bodies.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Indiana</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Hostetler, Karl Y" sort="Hostetler, Karl Y" uniqKey="Hostetler K" first="Karl Y." last="Hostetler">Karl Y. Hostetler</name></region><name sortKey="Aldern, Kathy A" sort="Aldern, Kathy A" uniqKey="Aldern K" first="Kathy A." last="Aldern">Kathy A. Aldern</name><name sortKey="Berg, Jerry Vande" sort="Berg, Jerry Vande" uniqKey="Berg J" first="Jerry Vande" last="Berg">Jerry Vande Berg</name><name sortKey="Brophy, Gregory T" sort="Brophy, Gregory T" uniqKey="Brophy G" first="Gregory T." last="Brophy">Gregory T. Brophy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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